Vitamine cu calitate USP

|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
![]() |
Background: Telomere length may be a marker of biological aging. Multivitamin supplements represent a major source of micronutrients, which may affect telomere length by modulating oxidative stress and chronic inflammation.
Results: Compared with nonusers, the relative telomere length of leukocyte DNA was on average 5.1% longer among daily multivitamin users (P for trend = 0.002). In the analysis of micronutrients, higher intakes of vitamins C and E from foods were each associated with longer telomeres, even after adjustment for multivitamin use.
Conclusion: This study provides the first epidemiologic evidence that multivitamin use is associated with longer telomere length among women.
Concluzie: Evidenta ca folosirea de MultiVitamine este asociat cu prelungirea de telomere la femei cu 5.1% - Telomere este un marker a varstei biologice
Telomere se scurteza cu diviziunea celulara

http://www.lef.org/newsletter/2009/0317_Longer-Telomeres-Associated-with-Multivitamin-Use.htm
Concentratia serica inalta de Vitamina D este asociat cu prelungirea de telomere la femei


Miracolul antioxidant |
Terapia
Anti-Aging cu antioxidanti
|
||||
![]() |
|
| Control Oftamologic | Vitamina A si Beta-Caroten pentru o vedere oculara mai buna |
![]() |
![]() |
| Caderea parului (alopecia areata) | Set Cura Alopecie-Fem cu: Extract dinSamburi de Struguri 125 mg + PABA 500 mg + Biotina 10 mg |
![]() |
![]() |
Unghie sanatoasa, unghie fragila

| MultiVitamine Minerale+Lecitina in cura cu suplimente nutritive produse-naturale | |
![]() |
![]() |
Structura normala de masa osoasa
|
Osteoporoza
|
La osteoporoza se subtiaza structura masei
osoase
|
![]() |
![]() |
![]() |
Fractura de femur la osteoporoza


Importanta vitaminei D si a calciului la osteoporoza

Minerale |
![]() |
| Recomandarea zilnica de Calciu | Necesarul de Calciu
|
||||||||||
![]() |
|

Produse-naturale ca: Acid Paraaminobenzoic PABA pentru ingrijirea pielii

Inositol tine glicemia sub control in terapia de hiperglicemie

Celule cu rezistenta insulinica

Colina Bitartrat un stimulator cerebral
| Creier sanatos | Creier cu Alzheimer |
![]() |
![]() |
|
Fructe
|
Zarzavaturi
|
||
|
Capsuni
|
Calciu - 55 %
|
Cartofi
|
Fosfor - 47 %
|
|
Pepene
|
Magneziu -
45 %
|
Fasole
|
Natriu -
100 %
|
|
Portocale
|
Fier -
67 %
|
Morcovi
|
Magneziu -
75 %
|
|
Mure
|
Calciu -
35 %
|
Brocoli
|
Calciu - 75 %
|
|
Zmeura
|
Calciu -
39 %
|
Spanac
|
Fier -
60 %
|
| Cultura intensiva | Ingrasamintele
chimice, ierbicide,
|
combaterea daunatorilor, |
![]() |
sint cauze ca: Fructele si zarzavaturile scad din calitate tot mai mult. | ![]() |
|
|
|
|
|
|

Fructe si Zarzavaturi - Ieri si Astazi. Studiu pe o perioada de 10 ani |
||||
|
Fructe si Zarzavaturi
|
Vitamine si Minerale
|
1985
Continut mg/100g |
1996
Continut mg/100g |
Diferenta
|
|
Brocoli |
Calciu
Acid Folic Magneziu |
103
47 24 |
33
23 18 |
Minus 68%
Minus 52% Minus 25% |
| Cartofi |
Calciu
Acid Folic Magneziu Vitamina B6 |
56
39 26 140 |
34
34 22 55 |
Minus 38%
Minus 12% Minus 15% Minus 61% |
| Morcovi |
Calciu
Magneziu |
37
21 |
31
9 |
Minus 17
%
Minus 57% |
| Spanac |
Magneziu
Vitamina B6 Vitamina C |
62
200 51 |
19
18 22 |
Minus 68%
Minus 59% Minus 58% |
| Banane |
Calciu
Acid Folic Magneziu Vitamin B6 |
8
23 31 330 |
7
3 27 22 |
Minus 12%
Minus 84% Minus 13% Minus 92% |
| Capsuni |
Calciu
Magneziu Vitamina C |
21
12 60 |
18
13 13 |
Minus 14%
Plus 8% Minus 67% |
Studiu: Sanatoriului Obertal |
||||
Trebuie sa ajutam organizmul printr-o varietate alimentara, prin sprijinirea alimentatiei cu suplimente nutritive si antioxidante protectoare.
| Depozitarea gresita a alimentelor | ||||
| Sensibilitatea vitaminelor la efectele externe | ||||
|
|
Aerul (oxigen)
|
Lumina
|
Caldura
|
Pierderi prin fierbere
|
|
Vitamina A
|
+++
|
+++
|
+
|
10 - 30 %
|
|
Vitamina C
|
++
|
++
|
++
|
20 - 80 %
|
|
Vitamina D
|
+++
|
++
|
+
|
putin
|
|
Vitamina E
|
+++
|
++
|
+
|
pina la 50
%
|
|
Vitamina B1
|
++
|
+
|
+++
|
30 - 50 %
|
|
Vitamina B2
|
+
|
+++
|
++
|
pina la 50
%
|
|
Vitamina B6
|
+
|
+++
|
++
|
pina la 20
%
|
|
Vitamina B12
|
++
|
++
|
+
|
20 - 80 %
|
|
Acid Folic
|
+
|
++
|
+++
|
pina la 90
%
|
| Explicatie: +++ = foarte Sensibile; ++ = Sensibile; + = Nesensibile. | ||||
Literatura: Ross Pelton si alti trei farmacisti James B. LaValle, Ernest B. Hawkins au elaborat in cartea "Drug-Induced Nutrient Depletion Handbook": Medicamentele efecte adverse - Reduc nivelul nutritional - Interfereaza absorbtia sau inhiba transportul in metabolism.
Medicamentele efecte adverse - Reduc nivelul nutritional in organism

Bibliografie-Referinte: MultiVitamine

Informatii din bibliografia electronica la tema: Nutritie si sanatate
1. Xu Q, Parks CG, Deroo LA, Cawthon RM, Sandler DP, Chen H. Multivitamin use
and telomere length in women. Am J
Clin Nutr. 2009 Mar 11
2
Benetos
A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A.
Telomere length as an indicator of biological aging: The gender
effect
and relation with pulse pressure and pulse wave velocity. Center "Investigations
Preventives et Cliniques" (IPC), INSERM U337, Paris, France. Hypertension. 2001 Feb;37(2):381-5.
3. Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X,
Surdulescu GL, Swaminathan R, Spector TD, Aviv A. Higher serum vitamin D concentrations
are associated with longer leukocyte telomere length in women. Twin Research
and Genetic Epidemiology, St Thomas' Hospital, King's College, London School
of Medicine, London, United Kingdom. Am J Clin Nutr. 2007 Nov;86(5):1420-5.
4.
Berdanier, C. Advanced Nutrition: Micronutrients. CRC Press, 1998.
- American
Academy of Pediatrics Committee on Nutrition. Vitamin and mineral supplement
needs of normal children in the United States. Pediatrics 66:1015-1020,
1980.
5
Chandra
K. Effect of vitamin and trace-element supplementation on immune responses
and infection in elderly subjects. The Lancet 1992 Nov 7;340(8828):1124-7.
6
Hercberg
S. Antioxidant micronutrients and chronic degenerative pathology: the role
of complementary nutritional doses. Bull Mem Acad R Med Belg 1997;152(10-11):379-85;
discussion 385-7.
- Packer, L. (1995): Oxidative Stress, Antioxidants, Aging and Disease. Oxidative
Stress and Aging; Birkhauser Verlag. 114.
7
Thurnham
DI, Northrop-Clewes CA. Optimal nutrition: vitamin A and the carotenoids.
Proc Nutr Soc. 1999;58(2):449-457.
- Wolf G. A history of vitamin A and retinoids. FASEB J. 1996; 10:1102-1107.
- Acott TS, Weleber RG. Vitamin A megatherapy for retinal abnormalities. Nature
Med. 1995; 1:884-885.
- Losonczy, K.G., et al. Vitamin E and vitamin C supplement use. American Journal
of Clinical Nutrition, 1996.
- Brown NA, Bron AJ, Harding JJ, Dewar HM. Nutrition supplements and the eye.
Eye 1998;12 ( Pt 1):127-33.
- Jacobson SG, Cideciyan AV, Regunath G, et al. Night blindness in Sorsby's fundus
dystrophy reversed by vitamin A. Nature Gen. 1995; 11:27-32.
8
Berson
EL, Rosner B, Sandberg MA, et
al. A
randomized trial of vitamin A and vitamin E supplementation for retinitis
pigmentosa. Arch Ophthalmol. 1993;111(6):761-772.
9
Robertson,
J., et al. A possible role for vitamins C and E in cataract prevention. American
Journal of Clinical Nutrition,
1991 supplement.
10
Albarracin
CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination
improves glucose metabolism in treated, uncontrolled
overweight
to obese patients with type 2 diabetes. Alpha Therapy Center, 4626 Weber
Road, Suite 100, Corpus Christi, TX 78411, USA. Diabetes Metab
Res Rev. 2008 Jan-Feb;24(1):41-51.
11
Albarracin
CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination
improves glucose metabolism in treated, uncontrolled overweight to obese
patients with type 2 diabetes. Alpha Therapy Center, 4626 Weber Road, Suite
100, Corpus
Christi, TX 78411, USA. Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51.
12
Mock
DM. Biotin. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition
in Health and Disease. 9th ed. Baltimore: Lippincott Williams & Wilkins; 1999:459-466.
- Mock DM. Biotin. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ,
eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore: Lippincott
Williams & Wilkins;
2006:482-497.
13
Floersheim
GL. Treatment of brittle fingernails with biotin. Z Hautkr. 1989 Jan 15;64(1):41-8.
14
Locksmith
GJ, Duff P. Preventing neural tube defects: the importance of periconceptional
folic acid supplements. Obstet Gynecol 1998 Jun;91(6):1027-34.
15
Bottiglieri
T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996;
54:382-390.
- Carmel R, Gott PS, Waters CH, et al. The frequency of low cobalamin levels
in dementia usually signify treatable metabolic, neurologic and electrophysiologic
abnormalities. Eur J Haematol. 1995; 54:245-253.
-Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused
by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med.
1988; 318:1720-1728.
- Bernstein AL. Vitamin B6 in clinical neurology. Ann NY Acad Sci. 1990; 585:250-260.
16
Weir
DG, Scott JM. Brain function in
the elderly: role of vitamin B12 and folate.
Br Med Bull. 1999; 55:669-682.
17
Bell,
I.R. et al. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant
treatment in geriatric depression
with cognitive dysfunction. J. Am. Coll.
Nutr. 1992; 11: 159-63.
18
Bender
DA. Optimum nutrition: thiamin, biotin and pantothenate. Proc Nutr
Soc. 1999;58(2):427-433.
- Powers HJ. Current
knowledge concerning optimum nutritional status of riboflavin, niacin and
pyridoxine. Proc Nutr Soc. 1999;58(2):435-440.
19
Green
KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla
FM. Nicotinamide restores cognition
in Alzheimer's disease transgenic
mice
via a mechanism involving sirtuin inhibition and selective reduction of
Thr231-phosphotau. Department of Neurobiology and Behavior, University of California,
Irvine,
Irvine, California
92697-4545, USA. J Neurosci. 2008 Nov 5;28(45):11500-10.
20
Vutyavanich
T, Wongtra-ngan S, Ruangsri R. Pyridoxine
for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled
trial. Am J Obstet
Gynecol. 1995;173(3 Pt 1):881-884.
21
Vaxman
F, Olender S, Lambert A, et al. Effect
of pantothenic acid and ascorbic acid supplementation on human skin wound
healing process. A double-blind, prospective and randomized trial. Eur Surg
Res.
1995;27(3):158-166.
22
Pauling
L. The significance of the evidence about ascorbic acid and the common
cold.Proc Natl Acad SciUSA. 1971; 68:2678-2681.
- Anon. Zinc lozenges reduce cold symptoms. Nutr Rev.
1997; 55:82-88.
23
Johnston,
C.S. "Recommendations
for Vitamin C Intake," JAMA, vol. 282, no. 22 (December 1999).
- Jha, P., et al., "The Antioxidant Vitamins and Cadiovascular Disease," Ann.
Of Intern. Med., vol. 123 (1995), pp. 860.
- Fidanza, A. et al. Vitamin C and cholesterol. Int. J. Vit. Nutr. Res. 1982;
23:153-171.
24
Jialal,
I., Fuller, C.J. Effect of vitamin E, Vitamin C and beta-carotene on LDL
oxidation and atherosclerosis.
Canad. J. Cardiol. 1995; 11, (Suppl G): 97-103.
- Kayden HJ, Traber M. Absorption,
lipoprotein transport and regulation of plasma concentrations of vitamin E
in humans. J Lipid Res. 1993; 34:343-358.
25
Vitamin
D supplementation and fracture incidence in elderly persons. A randomized,
placebo-controlled clinical trial. Ann Intern Med. 1996; 124:400-406.
- Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip
fractures. N Engl J Med. 1992; 327:1637-1642.
26
Lips
P, Graafmans WC, Ooms ME, et al. Vitamin
D supplementation and fracture incidence in elderly persons. A randomized,
placebo-controlled clinical trial. Ann Intern Med. 1996; 124:400-406.
- Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin
D3 and calcium to prevent hip
fractures. N Engl J Med. 1992; 327:1637-1642.
- O'Brien KO. Combined calcium and vitamin D supplementation reduces bone loss
and fracture incidence in older men and women. Nutr Rev. 1998; 56(5 Pt 1):148-150.
- LeBoff MS, Kohlmeier L, Hurwitz S, et al. Occult
vitamin D deficiency in postmenopausal
US women with acute hip fracture. JAMA. 1999; 281:1505-1511.
- Booth SL, Tucker
KL, Chen H, et al. Dietary
vitamin K intakes are associated with hip fracture but not with bone mineral
density in elderly men and women.Am J Clin Nutr. 2000; 71:1201-1208.
- Sarah L. Booth3, Ligia Martini, James W. Peterson, Edward Saltzman, Gerard
E. Dallal and Richard J. Wood. Dietary
Phylloquinone Depletion and Repletion in Older Women. Human Nutrition and Metabolism. Jean
Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging
at Tufts University, Boston,
MA 02111
- Feskanich D, Weber P, Willett WC, et al. Vitamin
K intake and hip fractures in women: a prospective study. Am J Clin Nutr.
1999; 69:74-79.
27
Fujita
T. Vitamin D in the treatment of osteoporosis. Proc Soc Exp Biol Med. 1992;
199:394-399.
- Amin S, La Valley MP, Simms RW, Felson DT. The role of vitamin D in corticosteroid-induced
osteoporosis. A meta-analytic approach. Arthritis Rheum. 1999; 42:1740-1751.
- Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention.
Proc Nutr Soc. 1997;56(3):915-937.
- Olson RE. Osteoporosis and vitamin K intake (editorial). Am J Clin Nutr. 2000;
71:1031-1032.
- Vermeer C, Jie KS, Knapen MH. Role of vitamin K in bone metabolism. Annu Rev
Nutr. 1995; 15:1-22.
- Heaney RP. Calcium,
dairy products and osteoporosis. J Am Coll Nutr. 2000;19(2
Suppl):83S-99S.
- Sojka JE, Weaver CM. Magnesium
supplementation and osteoporosis. Nutr Rev.
1995;53(3):71-74.
28
Chapuy
MC, Chapuy P, Thomas JL, Hazard MC, Meunier PJ. Biochemical effects of calcium
and vitamin D supplementation in elderly, institutionalized,
vitamin D-deficient patients. National Institute for Health and Medical
Research (INSERM) unit 403, Edouard Herriot Hospital, Lyon, France. Rev
Rhum Engl Ed. 1996 Feb;63(2):135-40.
29. Dawson-Hughes B. Calcium and vitamin D nutritional needs of elderly women.
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on
Aging at Tufts University, Boston, MA 02111, USA. J Nutr. 1996 Apr;126(4 Suppl):1165S-7S.
- Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD. Vitamin
D and bone health in the elderly. Am J Clin Nutr. 1982 Nov;36(5 Suppl):1014-31.
30.
McAlindon TE, Felson DT, Zhang Y, et al. Relation
of dietary intake and serum levels of vitamin D to progression of osteoarthritis
of the knee among participants in the Framingham study. Ann Int Med. 1996;
125:353-359.
- Lane NE, Gore L, Cummings SR, et al. Serum
vitamin D levels and incident changes of radiographic osteoarthritis. Arthritis
Rheum. 1999; 42:854-860.
31
Rapola
JM, Virtamo J, Ripatti S,
et al. Randomised
trial of alpha-tocopherol and beta-carotene supplements on incidence
of major coronary events in men
with previous myocardial infarction. Lancet. 1997;349(9067):1715-1720.
32
Chamiec,
T., Herbaczynska-Cedro, K., Ceremuzynski, L. Effects of antioxidant vitamin
C and E on signal-averaged electrocardiogram in acute myocardial infarction
Am. J. Cardiol.1996; 77, 4: 237-241
33
Gruppo
Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Dietary
supplementation with n-3 polyunsaturated fatty acids and vitamin
E after myocardial infarction: results of the GISSI-Prevenzione trial.
Gruppo
Italiano
per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet. 1999;354(9177):447-455.
34
Eidelman
RS, Hollar D, Hebert PR, Lamas GA, Hennekens CH. Randomized trials of vitamin
E in the treatment and prevention of cardiovascular disease. Arch
Intern Med. 2004;164(14):1552-1556.
- Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis
of randomised trials. Lancet. 2003;361(9374):2017-2023.
- Boaz M, Smetana S, Weinstein T, et al. Secondary prevention with antioxidants
of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled
trial. Lancet. 2000;356(9237):1213-1218.
- Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation
and cardiovascular events in high-risk patients. The Heart Outcomes Prevention
Evaluation Study Investigators. N Engl J Med. 2000;342(3):154-160.
- Shekelle PG, Morton SC, Jungvig LK, et al. Effect of supplemental vitamin E
for the prevention and treatment of cardiovascular disease. J Gen Intern Med.
2004;19(4):380-389.
Collins R, Peto R, Armitage J. The MRC/BHF Heart Protection Study: preliminary
results. Int J Clin Pract. 2002;56(1):53-56.
35
Stephens
NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised
controlled trial of vitamin E in patients with coronary
disease: Cambridge
Heart Antioxidant Study (CHAOS). Lancet. 1996;347(9004):781-786.
36
Steiner
M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular
disease. Nutr
Rev. 1999; 57:306-309.
- Dowd P, Zheng ZB. On
the mechanism of the anticlotting action of vitamin E quinone. Proc Natl
Acad Sci USA. 1995; 92:8171-8175.
- Blackwell GJ, Radkomski M, Moncada S. Inhibition of human platelet aggregation
by vitamin K. Throm Res. 1985; 37:103-114.
37
Rapola
JM, Virtamo J, Ripatti S, et al. Effects
of alpha-tocopherol and beta-carotene supplements on symptoms, progression,
and prognosis of angina pectoris. Heart. 1998; 79:454-458.
38
Gey
KF. Vitamins E plus C and interacting conutrients required for optimal health.
A critical and constructive review of epidemiology and supplementation
data regarding cardiovascular disease and cancer. Biofactors 1998;7(1-2):113-74.
- Khackik, F. et al. (1995) Lutein, lycopene and their oxidative metabolites
in chemoprevention of cancer. Journal of Cellular Biochemistry, Supplement 22:236-246.
39
Giovannucci,
E, et al. Multivitamin use, folate, and colon cancer in women in the Nurses'
Health Study.
Annals of Internal Medicine, 1998;129:517-524.
- White, E. Relationship between vitamin and calcium supplement use and colon
cancer. Cancer Epidemiology: Biomarkers and Prevention, 1997.
40
Bonn
D. Vitamin E may reduce prostate-cancer incidence. Lancet 1998 Mar 28;351(9107):961.
41
Davies
KM, Heaney RP, Recker RR, Lappe JM, Barger-Lux MJ, Rafferty K, Hinders
S. Calcium intake and body weight. J Clin Endocrinol Metabol. 2000;85(12):4635-4638.
- Dietary Calcium Reduces Body Weight Heaney, R.P., Davies, K.M., Barger-Lux,
M.J., "Calcium
and Weight: Clinical Studies," Journal of the American College of Nutrition, 21(2), 2002, pages 152S-155S.
- Lin YC, Lyle RM, McCabe LD, McCabe GP, Weaver CM, Teegarden D. Dairy calcium
is related to changes in body composition during a two-year exercise intervention
in young women. J Am Coll Nutr. 2000;19(6):754-760.
42
Regulation
of adiposity and obesity risk by dietary calcium: mechanisms and implications.
Zemel MB. 2002. J Am Coll Nutr 21: 146S-151S.
- Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by
dietary calcium. FASEB J. 2000;14(9):1132-1138.
- Shi H et al. 2001. Effects of dietary calcium on adipocyte lipid metabolism
and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB
J 5:291-293.
43
Heaney
RP, Dowell SD, Bierman J, Hale CA, Bendich A. Absorbability and cost effectiveness
in calcium supplementation.
J Am Coll Nutr 2001;20:239-46.
44
Kaats
GR. et al. A randomized double blind placebo controlled study of the effects
of chromium picolinate supplementation
on body composition. Curr. Ther. Res. Clin. Exp. 1998; 59:379-388.
- Kaats GR. et al. Effects of chromium picolinate supplementation on body
composition: A randomized double blind placebo controlled study. Curr. Ther.
Res. 1996; 57:747-756.
45
Kinsman
GD, Howard AN, Stone DL,
Mullins PA. Studies
in copper status and atherosclerosis. Biochem Soc Trans. 1990;18(6):1186-1188.
46
Klevay
LM. Cardiovascular disease from copper deficiency--a history. J Nutr.
2000;130(2S Suppl):489S-492S.
47
Suharno
D, West CE, Muhilal, Karyadi D, Hautvast JG. Supplementation
with vitamin A and iron for nutritional anaemia in pregnant women in West
Java, Indonesia. Lancet. 1993;342(8883):1325-1328.
48
Mauskop
A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines.
Clin Neurosci.
1998;5(1):24-27.
49
Peikert
A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium:
results from a prospective, multi-center, placebo-controlled and
double-blind
randomized study. Cephalalgia. 1996;16(4):257-263.
- Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of
migraine--a
double-blind placebo-controlled study. Cephalalgia. 1996;16(6):436-440.
50
Shechter
M, Merz CN, Paul-Labrador
M, et al. Oral
magnesium supplementation inhibits platelet-dependent thrombosis in patients
with coronary artery disease. Am J Cardiol. 1999;84(2):152-156.
- Shechter M, Sharir M, Labrador MJ, Forrester J, Silver B, Bairey Merz CN.
Oral magnesium therapy improves endothelial function in patients with coronary
artery
disease. Circulation. 2000;102(19):2353-2358.
51
Das
A, Jr., Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride,
TRH122 low molecular
weight sodium chondroitin sulfate and manganese ascorbate in the management
of knee osteoarthritis. Osteoarthritis Cartilage. 2000;8(5):343-350.
52
Wuebbens
MM, Liu MT, Rajagopalan K, Schindelin H. Insights
into molybdenum cofactor deficiency provided by the crystal structure
of the molybdenum cofactor biosynthesis protein MoaC. Structure Fold
Des. 2000;8(7):709-718.
53
Remer
T, Neubert A, Manz F. Increased
risk of iodine deficiency with vegetarian nutrition. Br J Nutr. 1999;81(1):45-49.
- Davidsson L. Are vegetarians an 'at risk group' for iodine deficiency
Br J Nutr. 1999;81(1):3-4.
54
Zimmerman
MB and Kohrle J. The impact of iron and selenium deficiencies on
iodine and thyroid metabolism:
biochemistry
and relevance to public health. Thyroid 2002;12:867-78.
55
Clark
LC, Combs Jr GF, Turnbull BW, Slate EH, Chalker D, Chow J, Davis LS, Glover
RA, Graham GF, Gross EG,
Krongrad A, Lesher JL, Park HK, Sanders BB, Smith CL, Taylor JR. Effects
of selenium supplementation for cancer prevention in patients with carcinoma
of the skin. A randomized controlled trial. J Am Med Assoc 1996;276:1957-63.
56
Block,
G. Vitamin C and cancer prevention, American Journal of Clinical Nutrition,
1991 supplement.
- Clark, L. C. et al. Effects of selenium supplementation for cancer prevention,
Journal of the American
Medical Association, 1996.
57
Oakley
GP Jr. Eat
right and take a multivitamin. N Engl J Med 1998 Apr 9;338(15):1060-1.
58. Sieve
BF. The clinical effects of a new B complex factor, para-aminobenzoic acid,
on pigmentation and fertility. South Med Surg. 1942;104:135–139.
59
Zarafonetis,
CJ. Darkening of gray hair during para-amino-benzoic acid therapy. J Invest
Dermatol. 1950
Dec;15(6):399-401.
- Zvak, C. The Science of Hair Care, 1986, Marcel Dekker, Inc., New York.
60. Brandaleone,
H., Maine, E., and Steele, J.M. The effect of calcium panthothenate and para-aminobenzoic
acid on gray hair in man. Am J Medical Science, 1944,
206: 315.
61. Kligman
AM. Early destructive effect of sunlight on human skin. JAMA. 1969 Dec
29;210(13):2377-80.
62
Kligman
LH, Akin FJ, Kligman AM. Sunscreens prevent ultraviolet photocarcinogenesis.
J Am Acad Dermatol. 1980 Jul;3(1):30-5.
63
Synder
DS, May M. Ability of PABA to protect mammalian skin from ultraviolet light-induced
skin tumors and actinic damage. J Invest Dermatol. 1975 Dec;65(6):543-6.
64
Willis
I, Kligman AM. Aminobenzoic acid and its esters. The quest for more effective
sunscreens. Arch Dermatol. 1970 Oct;102(4):405-17.
65. Silver SM, Schroeder BM, Sterns RH. Brain uptake of myoinositol after
exogenous administration. Department of Medicine, Rochester General Hospital,
University
of Rochester School of Medicine, Rochester, New York 14621, USA. J Am Soc
Nephrol. 2002 May;13(5):1255-60.
66. Schmidt RE, Plurad SB, Coleman BD, Williamson JR, Tilton RG. Effects of
sorbinil, dietary myo-inositol supplementation, and insulin on resolution
of neuroaxonal
dystrophy in mesenteric nerves of streptozocin-induced diabetic rats. Department
of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Diabetes. 1991 May;40(5):574-82.
67. Gregersen G, Bertelsen B, Harbo H, Larsen E, Andersen JR, Helles A, Schmiegelow
M, Christensen JE. Oral supplementation of myoinositol: effects on peripheral
nerve function in human diabetics and on the concentration in plasma, erythrocytes,
urine and muscle tissue in human diabetics and normals. Acta Neurol Scand.
1983 Mar;67(3):164-72.
68. Clements RS Jr, Vourganti B, Kuba T, Oh SJ, Darnell B. Dietary myo-inositol
intake and peripheral nerve function in diabetic neuropathy. Metabolism.
1979 Apr;28(4 Suppl 1):477-83.
69. Salway JG, Whitehead L, Finnegan JA, Karunanayaka A, Barnett D, Payne RB.
Effect of myo-inositol on peripheral-nerve function in diabetes. Lancet.
1978 Dec 16;2(8103):1282-4.
70. Khandelwal M, Reece EA, Wu YK, Borenstein M. Dietary myo-inositol therapy
in hyperglycemia-induced embryopathy. Department of Obstetrics, Temple University
School of Medicine, Philadelphia, Pennsylvania 19140, USA. Teratology. 1998
Feb;57(2):79-84.
71. Reece EA, Khandelwal M, Wu YK, Borenstein M. Dietary
intake of myo-inositol and neural tube defects in offspring of diabetic
rats. Department of Obstetrics,
Gynecology, and Reproductive Sciences, Temple University School of Medicine,
Philadelphia, PA 19140, USA. Am J Obstet Gynecol. 1997 Mar;176(3):536-9.
72. Gelber D, Levine J, Belmaker RH. Effect of inositol on bulimia nervosa
and binge eating. Ministry of Health Mental Health Center, Faculty of Health
Sciences,
Ben Gurion University of the Negev, P.O. Box 4600, Beersheva, Israel. Int
J Eat Disord. 2001 Apr;29(3):345-8.
73. Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Belmaker RH.
Double-blind, controlled trial of inositol treatment of depression. Yehuda
Abarbanel Mental
Health Center, Bat Yam, Israel. Am J Psychiatry. 1995 May;152(5):792-4.
- Levine J, Barak Y, Kofman O, Belmaker RH. Follow-up and relapse analysis of
an inositol study of depression. Abarbanel Mental Health Center, Bat Yam, Israel.
Isr J Psychiatry Relat Sci. 1995;32(1):14-21.
74. Chengappa KN, Levine J, Gershon S, Mallinger AG, Hardan A, Vagnucci A,
Pollock B, Luther J, Buttenfield J, Verfaille S, Kupfer DJ. Inositol as an
add-on treatment
for bipolar depression. Western Psychiatric Institute and Clinic, University
of Pittsburgh School of Medicine, PA, USA. Bipolar Disord. 2000 Mar;2(1):47-55.
75. Benjamin J, Agam G, Levine J, Bersudsky Y, Kofman O, Belmaker RH. Inositol
treatment in psychiatry. Division of Psychiatry, Faculty of Health Sciences,
Ben Gurion University of the Negev, Beersheva, Israel. Psychopharmacol Bull.
1995;31(1):167-75.
- Benjamin J, Agam G, Levine J, Bersudsky Y, Kofman O, Belmaker RH. Inositol
treatment in psychiatry. Division of Psychiatry, Faculty of Health Sciences,
Ben Gurion University of the Negev, Beersheva, Israel. Psychopharmacol Bull.
1995;31(1):167-75. Levine J. Controlled trials of inositol in psychiatry. Ministry
of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University
of the Negev, Beersheva, Israel. Eur Neuropsychopharmacol. 1997 May;7(2):147-55.
76. Wurtman RJ, Hefti F, Melamed E. Precursor control of neurotransmitter synthesis.
Pharmacol Rev. 1981; 32:315-335.
77. Higgins JP, Flicker L. Lecithin
for dementia and cognitive impairment. MRC Biostatistics Unit, Institute
of Public Health, Robinson Way, Cambridge, Cambridgeshire, UK, CB2 2SR.
Cochrane Database Syst Rev. 2000;(4):CD001015.
78. Whitehouse PJ. The
cholinergic deficit in Alzheimer's disease. Department of Behavioral and
Geriatric Neurology, Case Western Reserve University, University Alzheimer
Center, Cleveland, Ohio 44120-5000, USA. J Clin Psychiatry. 1998;59 Suppl
13:19-22.
79. Canty DJ, Zeisel SH. Lecithin and choline
in human health and
disease. Nutr Rev. 1994; 52:327-339.
80. Harris CM, Dysken MW, Fovall P, Davis
JM. Effect of lecithin on memory in normal adults. American Journal of Psychiatry.
1983;140(8):1010-1012.
81. Higgins JP, Flicker L. Lecithin for dementia and cognitive impairment.
Cochrane Database System Review. 2000;(4):CD001015.
- "Brain-specific" nutrients:
a memory cure McDaniel MA, Maier SF, Einstein GO. Nutrition. 2003 Nov-Dec;19(11-12):957-75.
82. Barbeau A. Emerging treatments: replacement
therapy with choline or lecithin in neurological diseases. Canadian Journal
of Neurological Sciences. 1978;5(1):157-160.
- Pomara N, Domino EF, Yoon H, Brinkman S, Tamminga CA, Gershon S. Failure
of single-dose lecithin to alter aspects of central cholinergic activity
in Alzheimer's
disease. Journal of Clinical Psychiatry. 1983;44(8):293-295.
- Barbeau A. Lecithin in Parkinson's disease. Journal of Neural Transmission
Supplement. 1980;(16):187-193.
Little A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled
trial of high-dose lecithin in Alzheimer's disease. Journal of Neurology, Neurosurgery,
and Psychiatry. 1985;48(8):736-742.
- Perryman KM, Fitten LJ. Delayed matching-to-sample performance during a double-blind
trial of tacrine (THA) and lecithin in patients with Alzheimer's disease. Life
Science. 1993;53(6):479-486.
- Maltby N, Broe GA, Creasey H, Jorm AF, Christensen H, Brooks WS. Efficacy of
tacrine and lecithin in mild to moderate Alzheimer's disease: double-blind trial.
British Medical Journal 1994;308(6933):879-883.
83
Little
A, Levy R, Chuaqui-Kidd P, Hand D. A double-blind, placebo controlled trial
of high-dose lecithin in Alzheimer's disease. Journal of Neurology, Neurosurgery,
and Psychiatry. 1985;48(8):736-742.
- Perryman KM, Fitten LJ. Delayed matching-to-sample performance during a double-blind
trial of tacrine (THA) and lecithin in patients with Alzheimer's disease. Life
Science. 1993;53(6):479-486.
- Maltby N, Broe GA, Creasey H, Jorm AF, Christensen H, Brooks WS. Efficacy of
tacrine and lecithin in mild to moderate Alzheimer's disease: double-blind trial.
British Medical Journal 1994;308(6933):879-883.
84
Fitten
LJ, Perryman KM, Gross PL, Fine H, Cummins J, Marshall C. Treatment of Alzheimer's
disease with short- and long-term oral THA and lecithin: a double-blind study.
American Journal of Psychiatry. 1990;147(2):239-242.
85
Brinkman
SD, Smith RC, Meyer JS, et al. Lecithin and memory training in suspected Alzheimer's
disease. Journal of Gerontology. 1982;37(1):4-9.
86
The
effect of long-term high dose lecithin on erythrocyte choline transport in
Alzheimer patients. Uney JB, Jones GM, Rebeiro A, Levy R Biol Psychiatry 1992
Mar 15 31:6
630-3
87
Simons
LA, Hickie JB, Ruys J. Treatment of hypercholesterolaemia with oral lecithin.
Australia and New Zealand Journal
of Medicine. 1977;7(3):262-266.
88
Spilburg
CA, Goldberg AC, McGill JB, et al. Fat-free foods supplemented with soy stanol-lecithin
powder reduce cholesterol absorption and LDL cholesterol. Journal of the American
Dietetic Association. 2003;103(5):577-581.
89
Buchman
AL, Dubin M, Jenden D, et al. Lecithin increases plasma free choline and decreases
hepatic steatosis in long-term total parenteral nutrition patients. Gastroenterology.
1992;102(4 Pt 1):1363-1370.
90
Lecithin
and choline in human health and disease. Canty DJ, Zeisel SH Nutr Rev 1994
Oct 52:10 327-39
- Blusztajn JK.Choline, a vital amine. Department of Pathology, Boston University
School of Medicine, Boston, MA 02118, USA.Science. 1998 Aug
7;281(5378):794-5.
91
Hayashi
H, Tanaka Y, Hibino H, Umeda Y, Kawamitsu H, Fujimoto H, Amakawa T. Beneficial
effect of salmon roe phosphatidylcholine in chronic liver disease. Current
Medical Research Opinion. 1999;15(3):177-184.
Parerea din pasajele acestui site nu a fost independent cercetate sau confirmate.