|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
50
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Graviola (Annona muricata) cu substantele active in frunze |
 |
51
Graviola cu noul citotoxic anticancer
mono tetra hidro furan acetogenina, annomuricina A, B, C si muricatocina
C din frunzele de Annona muricata
52 Graviola cu substantele
active in frunze de mono tetra hidro furan acetogenina cu actiune la carcinomul pulmonar (A-549)
si carcinom de colon (HT-29),
53 Graviola cu noul citotoxic anticancer
mono tetra hidro furan Annonaceous acetogenina din Annona muricata
54 Graviola un anti-tumoral mono tetra hidro furan acetogenina din Annona muricata
55 Graviola (Annona muricata) cu continutul
de bullatacina are efect citostatic brevetat la adenocarcinomul mamar
| Graviola cu continutul de bullatacina are efect citostatic la adenocarcinomul mamar |
 |
56 Graviola cu continutul de bullatacina
un potent efectiv anti-tumoral inhiba virusul de hepatita B si cancerul
hepatic
57 Acetogenina un anticancer din Graviola
cu actiune selectiva de inhibare la mitocondria complex I
58 Acetogenina
un anticancer o substanta naturala din Graviola un inhibitor puternic
la mitocondria, regiunea NADH dehidrogenaza (complex I)
59 Acetogenina din Graviola un inhibitor
de cresterea celulelor tumorale de cancer
60 Graviola
un anti-cancer cu continutul de annonacina activitate citostatica la celulele de cancer
| Graviola (Annona muricata) cu annonacina un anti-tumoral cu activitate citostatica la celulele de cancer |
 |
Terapia Anti Aging:
Anti-Aging-Systeme
- Formula
AntiAging
Bibliografie - References: Referinte Anti cancer
Informatii din bibliografia electronica la tema: Nutritie si sanatate
1 Jeune MA, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts
and genistein in human breast cancer cells. Department of Biological Sciences,
Charles E. Schmidt College of Science, Florida Atlantic University, Davie,
FL
33314-7714, USA. celestre@iwon.com J Med Food. 2005 Winter;8(4):469-75.
2 Zhou HB, Chen JJ, Wang WX, Cai JT, Du Q. Anticancer activity of resveratrol
on implanted human primary gastric carcinoma cells in nude mice. Department of
Gastroenterology, Second Hospital of Zhejiang University, Hangzhou 310009, Zhejiang
Province, China. zhouhaibohz@163.com World
J Gastroenterol. 2005 Jan 14;11(2):280-4.
- Azmi AS, Bhat SH, Hadi SM. Resveratrol-Cu(II) induced DNA breakage in human
peripheral lymphocytes: implications for anticancer properties. Department of
Biochemistry, Faculty of Life Sciences, A.M.U. Aligarh 202 002, UP, India. FEBS
Lett. 2005 Jun 6;579(14):3131-5.
3 Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role
of resveratrol in prevention and therapy of cancer: preclinical and clinical
studies. Cytokine Research Laboratory, Department of Bioimmunotherapy, The University
of Texas M. D. Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston,
Texas 77030, USA. aggarwal@mdanderson.org Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
4 ElAttar TM, Virji AS. Modulating effect of resveratrol and quercetin on oral
cancer cell growth and proliferation. Hormone Research Laboratory, University
of Missouri-Kansas City, School of Dentistry, 64108-2784, USA. virjia@umkc.edu
Anticancer Drugs.
1999
Feb;10(2):187-93.
5 Garvin S, Ollinger K, Dabrosin C. Resveratrol induces apoptosis and inhibits
angiogenesis in human breast cancer xenografts in vivo. Division of Gynecologic
Oncology, Faculty of Health Sciences, University Hospital, SE-581 85 Linkoping,
Sweden. Cancer Lett. 2006 Jan 8;231(1):113-22.
6 Lu R, Serrero G. Resveratrol, a natural product derived from grape, exhibits
antiestrogenic activity and inhibits the growth of human breast cancer cells.
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy,
Baltimore 21201, USA. J Cell Physiol.
1999 Jun;179(3):297-304.
- Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM. Estrogenic and
antiestrogenic properties of resveratrol in mammary tumor models. Program for
Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal
Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago,
Chicago, Illinois 60612, USA. Cancer Res. 2001 Oct 15;61(20):7456-63.
7 Yang SH, Kim JS, Oh TJ, Kim MS, Lee SW, Woo SK, Cho HS, Choi YH, Kim YH, Rha
SY, Chung HC, An SW. Genome-scale analysis of resveratrol-induced gene expression
profile in human ovarian cancer cells using a cDNA microarray. Microarray Division,
GenomicTree, Inc., Daejon 305-390, Korea. Int J Oncol. 2003 Apr;22(4):741-50.
8 Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth
NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity
of resveratrol, a natural product derived from grapes. Department of Medicinal
Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago,
Chicago, IL 60612, USA.Science. 1997 Jan10;275(5297):218-20.
9 Gescher AJ, Steward WP. Relationship between mechanisms, bioavailibility,
and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer
Biomarkers and Prevention Research Group, Department of Oncology, University
of Leicester, Leicester LE2 7LX, United Kingdom. ag15@le.ac.uk Cancer Epidemiol
Biomarkers Prev. 2003 Oct;12(10):953-7.
10 Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB. Resveratrol induces
growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression
in several human cancer cell lines. Herbert Irving Comprehensive Cancer Center,
Department of Medicine, College of Physicians and Surgeons of Columbia University,
New York, New York 10032,
USA. Clin Cancer Res. 2002 Mar;8(3):893-903.
11 Li ZG, Hong T, Shimada Y, Komoto I, Kawabe A, Ding Y, Kaganoi J, Hashimoto
Y, Imamura M. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal
tumorigenesis in F344 rats by resveratrol. Department of Surgery and Surgical
Basic Science, Graduate School of Medicine, Kyoto University, 54-Shogoin, Kawahra-cho,
Sakyoku, Kyoto
606-8507, Japan. Carcinogenesis. 2002 Sep;23(9):1531-6.
12 Schneider Y, Duranton B, Gosse F, Schleiffer R, Seiler N, Raul F. Resveratrol
inhibits intestinal tumorigenesis and modulates host-defense-related gene expression
in an animal model of human familial adenomatous polyposis. Laboratoire du Controle
Metabolique et Nutritionnel en Oncologie Digestive, l'Universite Louis Pasteur,
Institut de Recherche contre les Cancers de l'Appareil Digestif, 67091 Strasbourg,
France. Nutr Cancer. 2001;39(1):102-7.
13 Tessitore L, Davit A, Sarotto I, Caderni G. Resveratrol depresses the growth
of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Dipartimento
di Scienze Chimiche Alimentari Farmaceutiche e Farmacologiche, Universita del
Piemonte Orientale 'Amedeo Avogadro', Vercelli, Italy. Carcinogenesis.
2000 Aug;21(8):1619-22.
14 Busquets S, Ametller E, Fuster G, Olivan M, Raab V, Argiles JM, Lopez-Soriano
FJ. Resveratrol, a natural diphenol, reduces metastatic growth in an experimental
cancer model. Cancer Research Group, Departament de Bioquimica i Biologia Molecular,
Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona,
Spain. Cancer Lett. 2007 Jan 8;245(1-2):144-8. Epub 2006 Feb 7.
15 Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis
in vitro. Laboratory of Cell and Molecular Biology of Aging, Graduate School
of Nutritional and Environmental Sciences, University of Shizuoka, Yada, 422-8526,
Shizuoka,
Japan. Cancer Lett. 2001 Sep 28;171(1):11-6.
16 Blardi P, De Lalla A, Volpi L, Di Perri T. Stimulation of endogenous adenosine
release by oral administration of quercetin and resveratrol in man. Department
of Internal Medicine, University of Siena, Italy. Drugs Exp Clin Res. 1999;25(2-3):105-10.
17 Mertens-Talcott SU, Talcott ST, Percival SS. Low concentrations of quercetin
and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis
in MOLT-4 human leukemia cells. Food Science and Human Nutrition Department,
University of Florida, Gainesville, FL 32611, USA. J Nutr. 2003 Aug;133(8):2669-74.
18 S. Mertens-Talcott, S. Percival Ellagic acid and quercetin interact synergistically
with resveratrol in the induction of apoptosis and cause transient cell cycle
arrest in human leukemia cells. Department of Food Science and Human Nutrition,
Institute of Food and Agricultural Sciences, University of Florida, P.O. Box
110370, Gainesville, FL 32611-0370, USA Cancer Letters, Volume 218, Issue 2,
Pages 141-151
19 Albrecht
M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman
I, Geldof AA, Campbell MJ. Pomegranate extracts potently suppress
proliferation, xenograft growth, and invasion of human prostate cancer cells.
Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany.
J Med Food. 2004 Fall;7(3):274-83.
20 Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic
acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard
chemotherapy using vinorelbine and estramustine phosphate. Operative Unit of
Urology, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture,
Potenza, Italy. mayurol@yahoo.it Eur Urol. 2005 Apr;47(4):449-54; discussion
454-5. Epub 2005 Jan 19.
21 Adhami VM, Mukhtar H. Polyphenols from green tea and pomegranate for prevention
of prostate cancer. Department of Dermatology, University of Wisconsin-Madison,
Madison, WI 53706, USA. Free Radic Res. 2006 Oct;40(10):1095-104.
22 Seeram NP, Aronson WJ, Zhang Y, Henning SM, Moro A, Lee RP, Sartippour M,
Harris DM, Rettig M, Suchard MA, Pantuck AJ, Belldegrun A, Heber D. Pomegranate
ellagitannin-derived metabolites inhibit prostate cancer growth and localize
to the mouse prostate gland. J Agric Food Chem. 2007 Sep 19;55(19):7732-7. Epub
2007 Aug 28.
23 Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic
acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard
chemotherapy using vinorelbine and estramustine phosphate. Operative Unit of
Urology, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture,
Potenza, Italy. mayurol@yahoo.it Eur Urol. 2005 Apr;47(4):449-54; discussion
454-5. Epub 2005 Jan 19.
24 Mandal S, Stoner GD. Inhibition of N-nitrosobenzylmethylamine-induced esophageal
tumorigenesis in rats by ellagic acid. Department of Pathology, Medical College
of Ohio, Toledo 43699. Carcinogenesis. 1990 Jan;11(1):55-61.
25 Siglin JC, Barch DH, Stoner GD. Effects of dietary phenethyl isothiocyanate,
ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced
esophageal carcinogenesis in rats. Department of Pathology, Medical College of
Ohio, Toledo 43699-0008, USA. Carcinogenesis. 1995 May;16(5):1101-6.
26 Tanaka T, Iwata H, Niwa K, Mori Y, Mori H. Inhibitory effect of ellagic acid
on N-2-fluorenylacetamide-induced liver carcinogenesis in male ACI/N rats. First
Department of Pathology, Gifu University School of Medicine. Jpn J Cancer Res.
1988 Dec;79(12):1297-303.
27 Mukhtar H, Del Tito BJ, Marcelo CL, Das M, Bickers DR. Ellagic acid: a potent
naturally occurring inhibitor of benzo[a]pyrene metabolism and its subsequent
glucuronidation, sulfation and covalent binding to DNA in cultured BALB/C mouse
keratinocytes. Carcinogenesis. 1984;5(12):1565-1571.
28 Liao S, Umekita Y, Guo J, Kokontis JM, Hiipakka RA. Growth inhibition and
regression of human prostate and breast tumors in athymic mice by tea epigallocatechin
gallate. Cancer Lett. 1995;96:239-243.
- Carlin BI, Pretlow TG, Pretlow TP, et al. Green tea polyphenols inhibit growth
of PC xenograft cwr-22 and decrease ornithine decarboxylase activity: implications
for PC chemoprevention. J Urol 155: 510A, 1996.
29 Liao S, Hipakka, RA. Selective inhibition of steroid 5-alfa-reductase [5AR]
by tea epicatechin-3-gallate and epigallocatechin-3-gallate. Biochemical and
Biophysical Research Communications; 214(3), 833-838,1995).
- Gupta S, Ahmad N, Mukhtar H. Prostate cancer chemoprevention by green tea.
Semin Urol Oncol. 1999; 17:70-76.
- Suganuma M, Okabe S, Sueoka N, et al. Green tea and cancer chemoprevention.
Mutation Res. 1999; 428:339-344.
- Suganuma M, Okabe S, Kai Y, et al. Synergistic effects of (-)-epigallocatechin
gallate with (-)-epicatechin, sulindac or tamoxifen
on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer
Research 1999; 59: 44-47.
30. Waffo-Teguo P, Hawthorne ME, Cuendet M, Merillon JM, Kinghorn AD, Pezzuto
JM, Mehta RG. Potential cancer-chemopreventive activities of wine stilbenoids
and flavans extracted from grape (Vitis vinifera) cell cultures. Program for
Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal
Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago,
Chicago, IL 60612, USA. Nutr Cancer. 2001;40(2):173-9.
- Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss
HG, Stohs SJ, Bagchi D. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin
extract on cultured human cancer cells. Creighton University School of Pharmacy
and Allied Health Professions, Omaha, NE 68178, USA. Mol Cell Biochem. 1999 Jun;196(1-2):99-108.
31 Zhao J, Wang J, Chen Y, Agarwal R. Anti-tumor-promoting activity of a polyphenolic
fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion
protocol and identification of procyanidin B5-3'-gallate as the most effective
antioxidant constituent. Center for Cancer Causation and Prevention, AMC Cancer
Research Center, Denver, CO 80214, USA. Carcinogenesis. 1999 Sep;20(9):1737-45.
32 Agarwal C, Sharma Y, Agarwal R. Anticarcinogenic effect of a polyphenolic
fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation
of mitogenic signaling and cell-cycle regulators and induction of G1 arrest and
apoptosis. Center for Cancer Causation and Prevention, AMC Cancer Research Center,
Denver, Colorado 80214, USA. Mol Carcinog. 2000 Jul;28(3):129-38.
- Agarwal C, Singh RP, Agarwal R. Grape seed extract induces apoptotic death
of human prostate carcinoma DU145 cells via caspases activation accompanied by
dissipation of mitochondrial membrane potential and cytochrome c release. Department
of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health
Sciences Center, Denver, CO 80262, USA. Chapla.Agarwal@UCHSC.edu Carcinogenesis.
2002 Nov;23(11):1869-76.
33 Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract
inhibits advanced human prostate tumor growth and angiogenesis and upregulates
insulin-like growth factor binding protein-3. Department of Pharmaceutical Sciences,
School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO
80262, USA. Int J Cancer. 2004 Feb 20;108(5):733-40.
- Tyagi A, Agarwal R, Agarwal C. Grape seed extract inhibits EGF-induced and
constitutively active mitogenic signaling but activates JNK in human prostate
carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Department
of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health
Sciences Center, Denver 80262, USA. Oncogene. 2003 Mar 6;22(9):1302-16.
34 Agarwal C, Sharma Y, Zhao J, Agarwal R. A polyphenolic fraction from grape
seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells
by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest
and differentiation. Center for Cancer Causation and Prevention, AMC Cancer Research
Center, Denver, Colorado 80214, USA. Clin Cancer Res. 2000 Jul;6(7):2921-30.
- Singletary KW, Meline B. Effect of grape seed proanthocyanidins on colon aberrant
crypts and breast tumors in a rat dual-organ tumor model. Department of Food
Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA. kws@uiuc.edu
Nutr Cancer. 2001;39(2):252-8.
35 Kaur M, Singh RP, Gu M, Agarwal R, Agarwal C. Grape seed extract inhibits
in vitro and in vivo growth of human colorectal carcinoma cells. Department of
Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver
and Health Sciences Center, Denver, Colorado 80262, USA. Clin Cancer Res. 2006
Oct 15;12(20 Pt 1):6194-202.
36 Agarwal C, Singh RP, Dhanalakshmi S, Agarwal R. Anti-angiogenic efficacy
of grape seed extract in endothelial cells. Department of Pharmaceutical Sciences,
School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO
80262, USA. chapla.agarwal@UCHSC.edu Oncol Rep. 2004 Mar;11(3):681-5.
- Liviero L, Puglisis E. Antimutagenic activity of procyanidins from vitis vinfera.
Fitother 1994;65:203–9.
37 Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MM. High-dose
vitamin C versus placebo in the treatment of patients with advanced cancer who
have had no prior chemotherapy. A randomized double-blind comparison. N Engl
J Med. 1985 Jan 17;312(3):137-41.
38 Ip C. Interaction of vitamin C and selenium supplementation in the modification
of mammary carcinogenesis in rats.
J Nat Cancer Inst. 1986; 77:299-303.
- Zhang S, Hunter DJ, Forman MR, Rosner BA, Speizer FE, Colditz GA, Manson JE,
Hankinson SE, Willett WC. Dietary carotenoids and vitamins A, C, and E and risk
of breast cancer. Department of Nutrition, Harvard School of Public Health, Boston,
MA 02115, USA. Shumin.Zhang@channing.harvard.edu J Natl Cancer Inst. 1999 Mar
17;91(6):547-56.
39 Kurbacher CM, Wagner U, Kolster B, Andreotti PE, Krebs D, Bruckner HW. Ascorbic
acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin,
and paclitaxel in human breast carcinoma cells in vitro. Department of Gynecology
and Obstetrics, University of Bonn Medical Center, Germany. Cancer Lett. 1996
Jun 5;103(2):183-9.
40 Jarosz M, Dzieniszewski J, Dabrowska-Ufniarz E, et al. Effects of high dose
vitamin C treatment on Helicobacter pylori ingestion and total vitamin C concentration
in gastric juice. Eur J Cancer Prev. 1998; 7:449-454.
41 Zhang HM, Wakisaka N, Maeda O, Yamamoto T. Vitamin C inhibits the growth
of a bacterial risk factor for gastric carcinoma: Helicobacter pylori. Department
of Infectious Disease and Tropical Medicine, Research Institute International
Medical Center of Japan, Tokyo. Cancer. 1997 Nov 15;80(10):1897-903.
42 Padayatty
SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M. Vitamin
C pharmacokinetics: implications for oral and intravenous use. National
Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer
Institut, and the Clinical Center, National Institutes of Health, Bethesda, Maryland
20892-1372,
USA. Ann Intern Med. 2004 Apr 6;140(7):533-7.
43 Kojima N. Systematic synthesis
of antitumor annonaceous acetogenins. Graduate School of Pharmaceutical Sciences,
Osaka University, Suite, Osaka
565-0871, Japan. n-kojima@sagami.or.jp Yakugaku Zasshi. 2004 Oct;124(10):673-81.
44 Chang FR, Wu YC. Novel cytotoxic annonaceous acetogenins from Annona muricata.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung
807, Taiwan, Republic of China. J Nat Prod. 2001 Jul;64(7):925-31.
45 Lamartiniere CA, Cotroneo MS, Fritz WA, Wang J, Mentor-Marcel R, Elgavish
A. Genistein chemoprevention: timing and mechanisms of action in murine mammary
and prostate. Department of Pharmacology and Toxicology, University of Alabama
at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294, USA. J Nutr.
2002 Mar;132(3):552S-558S.
46 Barnes S. Effect of genistein on in vitro and in vivo models
of cancer. Department of Pharmacology, University of Alabama at Birmingham
35294. J Nutr. 1995 Mar;125(3 Suppl):777S-783S.
47 Yu Z, Li W. Induction of apoptosis by puerarin in colon cancer HT-29 cells.
School of Public Health, Zhengzhou University, Zhengzhou 450052, China. yuzengli@263.net
Cancer Lett. 2006 Jul 8;238(1):53-60. Epub 2005 Aug 1.
48 Menon LG, Kuttan R, Nair MG, Chang YC, Kuttan G. Effect of isoflavones
genistein and daidzein in the inhibition of lung metastasis in mice induced
by B16F-10 melanoma cells. Amala Cancer Research Centre, Nagar, India. Nutr
Cancer. 1998;30(1):74-7.
49 Jaramillo MC, Arango GJ, González
MC, Robledo SM, Velez ID. Cytotoxicity and antileishmanial activity of Annona
muricata pericarp. Facultad de Química Farmacéutica, Universidad de Antioquia, A. A. 1226 Medellín, Colombia. Fitoterapia. 2000 Apr;71(2):183-6.
50 Kim GS, Zeng L, Alali F, Rogers LL, Wu FE, Sastrodihardjo S, McLaughlin
JL. Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from
the leaves of Annona muricata. Department of Medicinal Chemistry and Molecular
Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University,
West Lafayette, IN 47906, USA. Phytochemistry. 1998 Sep;49(2):565-71.
51 Wu FE, Gu ZM, Zeng L, Zhao GX, Zhang Y, McLaughlin JL, Sastrodihardjo S.
Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins
A and B, from the leaves of Annona muricata. Department of Medicinal Chemistry
and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University,
West Lafayette, Indiana 47907, USA. J Nat Prod. 1995 Jun;58(6):830-6.
- Wu FE, Zeng L, Gu ZM, Zhao GX, Zhang Y, Schwedler JT, McLaughlin JL, Sastrodihardjo
S. New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C
and muricatocin C, from the leaves of Annona muricata. Department of Medicinal
Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue
University, West Lafayette, Indiana 47907, USA. J Nat Prod. 1995 Jun;58(6):909-15.
52 Zeng L, Wu FE, Oberlies NH, McLaughlin JL, Sastrodihadjo S. Five new monotetrahydrofuran
ring acetogenins from the leaves of Annona muricata. Purdue University, School
of Pharmacy and Pharmacal Sciences, Department of Medicinal Chemistry and Molecular
Pharmacology, West Lafayette, Indiana 47907, USA. J Nat Prod. 1996 Nov;59(11):1035-42.
53 Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, Wu YC. New cytotoxic
monotetrahydrofuran annonaceous acetogenins from Annona muricata. Graduate
Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807,
Taiwan, Republic of China. J Nat Prod. 2002 Apr;65(4):470-5.
54 Tormo, J. R., et al. “In vitro
antitumor structure-activity relationships of threo/trans/threo mono-tetrahydro-furanic
acetogenins: Correlations with their inhibition of mitochondrial complex I.” Oncol. Res. 2003; 14(3): 147-54.
55 Oberlies NH, Croy VL, Harrison ML, McLaughlin JL. The Annonaceous acetogenin
bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma
cells. Department of Medicinal Chemistry and Molecular Pharmacology, School
of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333,
USA. Cancer Lett. 1997 May 1;115(1):73-9.
- Nicolas, H., et al. “Structure-activity
relationships of diverse Annonaceous acetogenins against multidrug resistant
human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102-6.
- J.L. McLaughlin and Y.-H. Hui, "Chemotherapeutically
Active Acetogenins," (bullatacin and bullatacinone) U.S. Patent No. 5,229,419, issued July 20, 1993.
56 Chih HW, Chiu HF, Tang KS, Chang FR, Wu YC. Bullatacin, a potent antitumor
annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell
line 2.2.15 by apoptosis induction. Fooyin Institute of Technology, Kaohsiung
County, Taiwan, ROC. Life Sci. 2001 Aug 3;69(11):1321-31.
57 Gonzalez-Coloma, A., et al. “Selective
action of acetogenin mitochondrial complex I inhibitors.” Z. Naturforsch. 2002; 57(11-12): 1028-34.
58 Degli Esposti M., Ghelli A., Ratta M., Cortes D. and Estornell E. (1994),
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors
of mitochondrial NADH dehydroganse (complex I). Dipartimento di Biologia, Università di
Bologna, Italy. Biochem J. 1994 July 1; 301(Pt 1): 161–167.
59 Oberlies NH, Jones JL, Corbett TH, Fotopoulos SS, McLaughlin JL. Tumor
cell growth inhibition by several Annonaceous acetogenins in an in vitro disk
diffusion assay. Department of Medicinal Chemistry and Pharmacognosy, School
of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333,
USA. Cancer Lett. 1995 Sep 4;96(1):55-62.
60 Yuan, S. S., et al. “Annonacin,
a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and
causes cytotoxicity in a Bax- and caspase-3-related pathway.” Life Sci. 2003 May: 72(25): 2853-61.
Parerea din pasajele acestui site nu a fost independent cercetate sau confirmate.
|
Anti-Aging-Systeme
© 2008
|
Design by NB |